I have a software RAID10 array (4-1TB drives) that I have assembled in a kvm vm on Proxmox (Debian Squeeze 6.0).  The HDDs were mapped to the vm using virtio.  The array once created and started in the vm (during resync) started throwing an I/O error on one of the disks.  It kept repeating the error until I stopped the array.  At the host level I ran smartctl on all drives and they all passed inspection.

The drives are not all the same brand.  The array is made up of 1 Seagate Barracuda, 2 WD Blacks, and 1 Hitachi.  The Seagate is an Advanced Format with sector size  (logical/physical) equal to 512B/4096B.  The other drives are standard format 512B/512B.  All drives are configured as GPT and have been partioned (using parted) to be aligned as follows:

Is it possible that the physical sector size of 4096B of the Seagate drive is causing the problem?  I don't believe that the I/O error was on the Seagate (I can't recall which it was on at the time).

The HDD's where mapped to virtio devices using the following:

qm <vmID> virtio# /dev/disk/by-id/ata-<disk name>

Any thoughts?