virtual email?

I've been reading up on how to setup virtual host with apache, but there is
one thing I can't figure out. How do I setup email(pop accounts, not
aliases) for all the different host? Can Sendmail even do this? Is there a
way to automate the making of virtual host along with "virtual email"? Ive
read DNS and BIND and Some of Sendmail(THe Oreilly ones). After reading
sendmail, I was left wondering if the only way to do it would be to run
multiple daemons or use another program.

John Albee